US 20 and WY 120 run directly into the heart of Thermopolis. The nearest interstate highway (I-25) is 130 miles away in Casper, WY.
Local (4,800 ft. runway); Worland Municipal (33 miles north); RIverton Regional (52 miles south); Yellowstone Regional (Cody-84 miles north); Casper International (130 miles east).
United Parcel Service, Federal Express, US Postal Service
Thermopolis is served by five trucking firms.